4-Nitrobenzenesulfonyl chloride → HCID 4572956, compound

HRID 552382Notes

Reaction equation

HRID 552382 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:14]([N:16]([CH2:20][CH3:21])[CH2:17][CH2:18][NH2:19])[CH3:15].C(N(CC)CC)C>C(Cl)Cl>[CH2:14]([N:16]([CH2:20][CH3:21])[CH2:17][CH2:18][NH:19][S:10]([C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)(=[O:12])=[O:11])[CH3:15]

Participants

5

Reactant 3

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 8471TriethylamineHCID 60993N,N-Diethylethylenediamine

Product 1

HCID 4572956HCID 4572956, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 4-nitrobenzenesulfonyl chloride (500 mg, 2.35 mmol), 2-diethylaminoethylamine (300 mg, 0.363 mL, 2.59 mmol) and triethylamine (262 mg, 0.359 mL, 2.59 mmol) in CH2Cl2 (7 mL) was stirred at room temperature for 18 hours. The mixture is then diluted with dichloromethane, and washed with brine. The organic layers is dried (MgSO4) and the solvent is removed under reduced pressure to yield the title compound, which is used as such for the next step.

Workup

  1. washwashed with brine
  2. dry with materialThe organic layers is dried (MgSO4)
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-9be977bf7f9c4654bd358718ab5c8f23
Source dataset
uspto-grants-2011_05
Patent number
US07951818B2

Reaction notes

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