HCID 9031607, compound → HCID 57424172, compound

HRID 552384Notes

Reaction equation

HRID 552384 reaction equation
[CH3:1][N:2]([CH3:23])[C:3]1[CH:22]=[CH:21][C:6]([CH2:7][NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1>CO.[Pd]>[NH2:18][C:15]1[CH:14]=[CH:13][C:12]([S:9]([NH:8][CH2:7][C:6]2[CH:21]=[CH:22][C:3]([N:2]([CH3:23])[CH3:1])=[CH:4][CH:5]=2)(=[O:10])=[O:11])=[CH:17][CH:16]=1

Participants

4

Reactant 1

HCID 9031607HCID 9031607, compound

Product 1

HCID 57424172HCID 57424172, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of N-(4-dimethylamino-benzyl)-4-nitro-benzenesulfonamide (472 mg, 1.409 mmol), prepared as described in D.1, in MeOH (10 ml) under nitrogen was added Pd/C 10% (74.92 mg, 0.007 mmol). The system was purged with hydrogen and let stirred overnight under an atmosphere of hydrogen. After filtration through a celite plug, the solvent is removed under reduced pressure to yield the title compound, which is used as such for the next step.

Workup

  1. customThe system was purged with hydrogen
  2. filtrationAfter filtration through a celite plug
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-93654cb901364cd48f31142714b371be
Source dataset
uspto-grants-2011_05
Patent number
US07951818B2

Reaction notes

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