Ammonium formate → HCID 43585050, compound

HRID 552387Notes

Reaction equation

HRID 552387 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][N:14]([CH:17]([CH3:19])[CH3:18])[CH2:13][CH2:12]1.C([O-])=O.[NH4+]>CO.[Zn]>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:12][CH2:13][N:14]([CH:17]([CH3:18])[CH3:19])[CH2:15][CH2:16]1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 574241741-(2-Chloro-4-nitrophenyl)-4-(1-methylethyl)piperazine

Product 1

HCID 43585050HCID 43585050, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1-(2-chloro-4-nitro-phenyl)-4-isopropyl-piperazine (1.500 g, 5.30 mmol), prepared according to example 5, in MeOH (20 mL) is added zinc dust (1.039 g, 15.90 mmol) followed by ammonium formate (1.002 g, 15.90 mmol). The reaction is stirred at room temperature. Once the reaction is finished, the reaction mixture is filtrated and concentrated. The mixture is taken up in dichloromethane and washed with water. The combined organic layers are dried (MgSO4) and the solvent is removed under reduced pressure to yield the title compound, which is used as such for the next step.

Workup

  1. filtrationthe reaction mixture is filtrated
  2. concentrationconcentrated
  3. washwashed with water
  4. dry with materialThe combined organic layers are dried (MgSO4)
  5. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-03c146668ed647f5b97013739dbdaf85
Source dataset
uspto-grants-2011_05
Patent number
US07951818B2

Reaction notes

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