反应详情

3-{4-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)-imidazo[1,2-a]pyridin-8-ylamino]-benzenesulfonylamino}-pyrrolidine-1-carboxylic acid tert-butyl ester (16 mg, 0.027 mmol), prepared using methods as described for compound 12, is suspended in a 4M solution of HCl in dioxane (0.5 mL) and the mixture is stirred under nitrogen at room temperature for 16 hours. The mixture is concentrated under reduced pressure. The crude product is purified by reverse phase HPLC to yield the title compound.

1. concentrationThe mixture is concentrated under reduced pressure
2. customThe crude product is purified by reverse phase HPLC