2-Chloro-5-fluoro-4-iodopyridine → 2'-Chloro-5'-fluoro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

HRID 552505노트

반응식

HRID 552505 반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[CH:15]=[C:14](B3OC(C)(C)C(C)(C)O3)[CH:13]=[C:12]([CH3:25])[N:11]=2)=[O:9])[S:5][CH:6]=1.[Cl:26][C:27]1[CH:32]=[C:31](I)[C:30]([F:34])=[CH:29][N:28]=1>>[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[CH:15]=[C:14]([C:31]3[C:30]([F:34])=[CH:29][N:28]=[C:27]([Cl:26])[CH:32]=3)[CH:13]=[C:12]([CH3:25])[N:11]=2)=[O:9])[S:5][CH:6]=1

참가 물질

3

반응물 2

HCID 248204952-Chloro-5-fluoro-4-iodopyridineHCID 497604122-Pyridinecarboxamide, 6-methyl-N-(4-methyl-2-thiazolyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-

생성물 1

HCID 248208922'-Chloro-5'-fluoro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

실험 절차

The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide in accordance with the general method of example 131, step 2 using 2-Chloro-5-fluoro-4-iodopyridine instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a off-white solid, MS (ISP): m/e=363.2, 365.1 (M+H)+.

출처 및 근거

ORD 기록
ord-0b8ba08de0ea46ec9fb905c926acec7c
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951824B2

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