3-Bromo-5-methylpyridine → 5,6'-Dimethyl-[3,4']bipyridinyl-2'-carboxylic acid (2-chloro-pyridin-4-yl)-amide

HRID 552514Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 552514
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[C:15](B3OC(C)(C)C(C)(C)O3)[CH:14]=[C:13]([CH3:26])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1.Br[C:28]1[CH:29]=[N:30][CH:31]=[C:32]([CH3:34])[CH:33]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([C:28]3[CH:29]=[N:30][CH:31]=[C:32]([CH3:34])[CH:33]=3)[CH:14]=[C:13]([CH3:26])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 8177133-Bromo-5-methylpyridineHCID 49760409N-(2-Chloropyridin-4-yl)-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamide

Produkt 1

HCID 866145875,6'-Dimethyl-[3,4']bipyridinyl-2'-carboxylic acid (2-chloro-pyridin-4-yl)-amide

Versuchsvorschrift

The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (2-chloro-pyridin-4-yl)-amide in accordance with the general method of example 131, step 2 using 3-Bromo-5-methylpyridine instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a white solid, MS (ISP): m/e=339.1, 341.1 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-0b79850825a643418be8b54e0960e754
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951824B2

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