(3,5-Difluorophenyl)boronic acid → 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10](Br)[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2].[F:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[C:19]([F:21])[CH:20]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10]([C:17]2[CH:16]=[C:15]([F:14])[CH:20]=[C:19]([F:21])[CH:18]=2)[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2]Participants
3
Procedure
The title compound, was prepared from 4-Bromo-6-methyl-pyridine-2-carboxylic acid ethyl ester (example 1, step 4) in accordance with the general method of example 1, step 6 using 3,5-Difluorophenylboronic acid instead of 3-Fluorophenylboronic acid to yield the final compound as a white crystalline solid, MS (ISP): m/e=278.1 (M+H)+.
Sources & evidence
- ORD record
- ord-812105f6cd444623a55950091e1ca7e0
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07951824B2
Reaction notes
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