2-Amino-5-methylpyridine → 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-pyridin-2-yl)-amide

HRID 552521Notes

Reaction equation

HRID 552521 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=1>>[CH3:28][C:25]1[CH:26]=[CH:27][C:22]([NH:21][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])=[N:23][CH:24]=1

Participants

3

Reactant 2

HCID 153482-Amino-5-methylpyridineHCID 671639994-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 671647404-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-pyridin-2-yl)-amide

Procedure

The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 2-Amino-5-methylpyridine instead of 3-chloroaniline to yield the final compound as a white crystalline, MS (ISP): m/e=340.2 (M+H)+.

Sources & evidence

ORD record
ord-95e8d3636df74509ab8c6d99673fd5e7
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

Loading…