Ammonia → 2-(2-amino-1,3-thiazol-4-yl)acetamide

HRID 552522Notes

Reaction equation

HRID 552522 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1[N:7]=[C:8]([NH2:11])[S:9][CH:10]=1)C.[NH3:13]>CO>[NH2:11][C:8]1[S:9][CH:10]=[C:6]([CH2:5][C:4]([NH2:13])=[O:3])[N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 70640912-(2-amino-1,3-thiazol-4-yl)acetamideYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2.5 g (15.0 mmol) (2-Amino-thiazol-4-yl)-acetic acid ethyl ester in 70 ml of 7N ammonia solution in methanol was stirred for 6 days at room temperature. After concentration in vacuo, one obtains 2.0 g (95%) of the title compound as a light brown solid, which was directly used in the next step without further purification.

Workup

  1. concentrationAfter concentration in vacuo, one

Sources & evidence

ORD record
ord-37aac4fe201f460184141f4b33d93d9b
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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