HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-(2-amino-1,3-thiazol-4-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Thiazoleacetic acid, 2-amino-, ethyl ester | HCID 104454 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(2-amino-1,3-thiazol-4-yl)acetamide | HCID 7064091 | 95% |
Reaction Steps
A solution of 2.5 g (15.0 mmol) (2-Amino-thiazol-4-yl)-acetic acid ethyl ester in 70 ml of 7N ammonia solution in methanol was stirred for 6 days at room temperature. After concentration in vacuo, one obtains 2.0 g (95%) of the title compound as a light brown solid, which was directly used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951824B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-37aac4fe201f460184141f4b33d93d9b |
| Source note | uspto-grants-2011_05 |