4-Aminopyridine-2-carbonitrile → 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid (2-cyano-pyridin-4-yl)-amide
Reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[CH:27]=[CH:26][N:25]=[C:24]([C:28]#[N:29])[CH:23]=1>>[C:28]([C:24]1[CH:23]=[C:22]([NH:21][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[CH:27]=[CH:26][N:25]=1)#[N:29]Participants
3
Procedure
The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 4-Amino-pyridine-2-carbonitrile instead of 3-chloroaniline to yield the final compound as a white crystalline, MS (ISP): m/e=351.2 (M+H)+.
Sources & evidence
- ORD record
- ord-6fb7de74acad4b828cead560ce561c59
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07951824B2
Reaction notes
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