ethyl 2-(3-amino-1H-pyrazol-1-yl)acetate → (3-{[4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carbonyl]-amino}-pyrazol-1-yl)-acetic acid ethyl ester
Reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[CH:26]=[CH:25][N:24]([CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[N:23]=1>>[CH2:31]([O:30][C:28](=[O:29])[CH2:27][N:24]1[CH:25]=[CH:26][C:22]([NH:21][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])=[N:23]1)[CH3:32]Participants
3
Procedure
The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using Ethyl (3-Amino-1-pyrazolyl)acetate instead of 3-chloroaniline to yield the final compound as a white crystalline, MS (ISP): m/e=401.2 (M+H)+.
Sources & evidence
- ORD record
- ord-4ab2db359ba041b287a1932c927f02a1
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07951824B2
Reaction notes
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