5-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl ester → 5-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid (4-cyclopentyl-thiazol-2-yl)-amide

HRID 552535Notes

Reaction equation

HRID 552535 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.Cl.[CH:21]1([C:26]2[N:27]=[C:28]([NH2:31])[S:29][CH:30]=2)[CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH:21]1([C:26]2[N:27]=[C:28]([NH:31][C:4]([C:6]3[CH:11]=[C:10]([C:12]4[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=4)[CH:9]=[C:8]([CH3:19])[N:7]=3)=[O:5])[S:29][CH:30]=2)[CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 671647705-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl esterHCID 1317289314-Cyclopentyl-1,3-thiazol-2-amine hydrochloride

Product 1

HCID 248209075-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid (4-cyclopentyl-thiazol-2-yl)-amide

Procedure

The title compound, was prepared from 5-Fluoro-6′-methyl-[3,4′]bipyridinyl-2′-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 4-Cyclopentyl-thiazol-2-ylamine, hydrochloride instead of 3-chloroaniline to yield the final compound as a white solid, MS (ISP): m/e=383 [M]+.

Sources & evidence

ORD record
ord-64779f3a773a43f19805d7f43d6dc469
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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