4-Fluoroaniline → 5-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid (4-fluoro-phenyl)-amide

HRID 552538Notes

Reaction equation

HRID 552538 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[F:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 671647705-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl ester

Product 1

HCID 671639745-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid (4-fluoro-phenyl)-amide

Procedure

The title compound, was prepared from 5-Fluoro-6′-methyl-[3,4′]bipyridinyl-2′-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 4-Fluoroaniline instead of 3-chloroaniline to yield the final compound as a gray solid, MS (ISP): m/e=324.9, 326.2 (M+H)+.

Sources & evidence

ORD record
ord-fdf49f94fb6b4e46bdf0f2d642ee0cf6
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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