Aniline → 5-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid phenylamide

HRID 552539Notes

Reaction equation

HRID 552539 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:21]1([NH:20][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 671647705-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl ester

Product 1

HCID 671629545-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid phenylamide

Procedure

The title compound, was prepared from 5-Fluoro-6′-methyl-[3,4′]bipyridinyl-2′-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using Aniline instead of 3-chloroaniline to yield the final compound as a white solid, MS (ISP): m/e=308.3, 309.3 (M+H)+.

Sources & evidence

ORD record
ord-cf726e268d404d85bd70362fb4cb4b46
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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