2-Chloropyridine-4-boronic acid → 2'-Chloro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid ethyl ester

HRID 552540Notes

Reaction equation

HRID 552540 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10](Br)[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2].[Cl:14][C:15]1[CH:20]=[C:19](B(O)O)[CH:18]=[CH:17][N:16]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10]([C:19]2[CH:18]=[CH:17][N:16]=[C:15]([Cl:14])[CH:20]=2)[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 51515952-Chloropyridine-4-boronic acidHCID 25208981Ethyl 4-bromo-6-methylpicolinate

Product 1

HCID 866145902'-Chloro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid ethyl ester

Procedure

The title compound, was prepared from 4-Bromo-6-methyl-pyridine-2-carboxylic acid ethyl ester (example 1, step 4) and 2-Chloropyridine-4-boronic acid in accordance with the general method of example 1, step 6 to yield the final compound as a light yellow oil, MS (ISP): m/e=277.1 (M+H)+.

Sources & evidence

ORD record
ord-f711cc18762345cba6efb52829fab4fb
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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