2-Amino-5-chloropyridine → 2'-Chloro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (5-chloro-pyridin-2-yl)-amide

HRID 552542Notes

Reaction equation

HRID 552542 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([Cl:18])[CH:13]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][N:22]=1>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([NH:20][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([Cl:18])[CH:13]=3)[CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])=[N:22][CH:23]=1

Participants

3

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 866145902'-Chloro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid ethyl ester

Product 1

HCID 866145922'-Chloro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (5-chloro-pyridin-2-yl)-amide

Procedure

The title compound, was prepared from 2′-Chloro-6-methyl-[4,4′]bipyridinyl-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 2-amino-5chloropyridine instead of 3-chloroaniline to yield the final compound as a white crystalline, MS (ISP): m/e=359.0, 361.1 (M+H)+.

Sources & evidence

ORD record
ord-643de7ccc3a444a894f7de66ab43fe01
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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