反应详情

A stirred solution of 4-(3-methanesulfonyl-phenoxy)-benzoic acid methyl ester (1.0 mmol) (see Intermediate 12) in 1:1 methanol/tetrahydrofuran (0.15 M), is treated with 2 N sodium hydroxide (3.0 mmol) and heated to reflux for one hour. The reaction is concentrated in vacuo. 1 N Hydrochloric acid and water are added and the mixture extracted with 10% isopropanol/dichloromethane. The organic portion is concentrated in vacuo to yield the desired product. MS (m/e): 291.0 (M−1).

1. temperatureheated
2. temperatureto reflux for one hour
3. concentrationThe reaction is concentrated in vacuo
4. addition1 N Hydrochloric acid and water are added
5. extractionthe mixture extracted with 10% isopropanol/dichloromethane
6. concentrationThe organic portion is concentrated in vacuo