HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(3-Methanesulfonyl-phenoxy)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(3-Methanesulfonyl-phenoxy)-benzoic acid methyl ester | HCID 67165231 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 4-(3-Methanesulfonyl-phenoxy)-benzoic acid | HCID 43807118 | — |
Reaction Steps
A stirred solution of 4-(3-methanesulfonyl-phenoxy)-benzoic acid methyl ester (1.0 mmol) (see Intermediate 12) in 1:1 methanol/tetrahydrofuran (0.15 M), is treated with 2 N sodium hydroxide (3.0 mmol) and heated to reflux for one hour. The reaction is concentrated in vacuo. 1 N Hydrochloric acid and water are added and the mixture extracted with 10% isopropanol/dichloromethane. The organic portion is concentrated in vacuo to yield the desired product. MS (m/e): 291.0 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951826B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-b5a64fae860540e3bccdde31c0487644 |
| Source note | uspto-grants-2011_05 |