反应详情

In a solution of 22.7 g of 3,5-dichloro-1-(1-trifluoromethylethenyl)benzene produced in Step 1 and 26.0 g of 4-bromo-α-chloro-3-methylbenzaldoxime produced in Step 2 in 120 mL of tetrahydrofuran, 15.7 g of potassium hydrogen carbonate was added, and stirred under reflux with heat for 5 hours. After the completion of the reaction, the reaction mixture was left and cooled to room temperature, insoluble material was filtered off, and then the solvent was distilled off under reduced pressure. 150 mL of water was added in the residue, stirred at room temperature for 18 hours, and then precipitated crystal was filtered off, and dried to obtain 38.6 g of the aimed product as white crystal.

1. temperatureunder reflux
2. temperaturewith heat for 5 hours
3. customAfter the completion of the reaction
4. waitthe reaction mixture was left
5. filtrationinsoluble material was filtered off
6. distillationthe solvent was distilled off under reduced pressure
7. addition150 mL of water was added in the residue
8. stirringstirred at room temperature for 18 hours
9. customprecipitated crystal
10. filtrationwas filtered off
11. customdried