反应详情

0.08 mmol 3-(4-Trifluoromethyl-phenyl)-2,5-dihydro-1H-pyrrole was dissolved in MeOH and HCl in ether was added until pH 1. After 5 minutes stirring, the solvents were evaporated. To a solution of this salt in 0.7 ml methanol under argon was added 2 mg Pd/C 10% and the mixture was hydrogenated under atmospheric pressure of hydrogen at room temperature for 4 h. The mixture was cooled, flushed with argon, diluted with methanol, filtered and the solvent was removed in vacuo to yield the title compound (64%) as an oil MS (m/e): 216.3 ([M+1], 100%).

1. customthe solvents were evaporated
2. additionTo a solution of this salt in 0.7 ml methanol under argon was added 2 mg Pd/C 10%
3. waitthe mixture was hydrogenated under atmospheric pressure of hydrogen at room temperature for 4 h
4. temperatureThe mixture was cooled
5. customflushed with argon
6. additiondiluted with methanol
7. filtrationfiltered
8. customthe solvent was removed in vacuo