Ethanol → HCID 67165624, compound

HRID 552711Notes

Reaction equation

HRID 552711 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@H:11]1[C@@H:15]2[O:16][C:17]([CH3:20])([CH3:19])[O:18][C@@H:14]2[C@@H:13]([CH2:21][CH2:22][S:23]([NH2:26])(=[O:25])=[O:24])[O:12]1.[NH2:27][C@@H:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:30][CH2:29]1.C(N(CC)C(C)C)(C)C.C(O)C>>[CH:28]1([NH:27][C:2]2[N:10]=[CH:9][N:8]=[C:7]3[C:3]=2[N:4]=[CH:5][N:6]3[C@H:11]2[C@@H:15]3[O:16][C:17]([CH3:20])([CH3:19])[O:18][C@@H:14]3[C@@H:13]([CH2:21][CH2:22][S:23]([NH2:26])(=[O:25])=[O:24])[O:12]2)[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:30][CH2:29]1

Participants

5

Reactant 4

HCID 702EthanolHCID 81531DiisopropylethylamineHCID 70000841-Aminoindane, (S)-HCID 86607313HCID 86607313, compound

Product 1

HCID 67165624HCID 67165624, compound

Procedure

2-[(3aR,4R,6R,6aR)-6-(6-Chloro-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-ethanesulfonamide (45.0 mg, 0.000111 mol), (S)-(+)-1-aminoindane (20.0 μL, 0.000156 mol) and N,N-diisopropylethylamine (24.0 μL, 0.000138 mol) were dissolved in ethanol (1.25 mL, 0.0214 mol) and reacted in a microwave at 140° C. for 10 minutes. The mixture was then concentrated in vacuo and used crude in the next step.

Workup

  1. customreacted in a microwave at 140° C. for 10 minutes
  2. concentrationThe mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-694e9de8940245c482aeea79f4558c49
Source dataset
uspto-grants-2011_05
Patent number
US07951810B2

Reaction notes

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