Water → HCID 58296133, compound

HRID 552712Notes

Reaction equation

HRID 552712 reaction equation
FC(F)(F)C(O)=O.O.[CH:9]1([NH:18][C:19]2[N:27]=[CH:26][N:25]=[C:24]3[C:20]=2[N:21]=[CH:22][N:23]3[C@H:28]2[C@@H:32]3[O:33]C(C)(C)[O:35][C@@H:31]3[C@@H:30]([CH2:38][CH2:39][S:40]([NH2:43])(=[O:42])=[O:41])[O:29]2)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1>>[C@@H:9]1([NH:18][C:19]2[N:27]=[CH:26][N:25]=[C:24]3[C:20]=2[N:21]=[CH:22][N:23]3[C@@H:28]2[O:29][C@H:30]([CH2:38][CH2:39][S:40]([NH2:43])(=[O:42])=[O:41])[C@@H:31]([OH:35])[C@H:32]2[OH:33])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1

Participants

4

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 67165624HCID 67165624, compound

Product 1

HCID 58296133HCID 58296133, compoundYield 45%

Procedure

Trifluoroacetic acid (3.60 mL, 0.0467 mol) was added to water (0.40 mL, 0.022 mol) and the mixture was added to 2-[(3aR,4R,6R,6aR)-6-(6-(indan-1-ylamino)-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-ethanesulfonamide (crude, 0.000111 mol). The reaction was left to stand (with occasional shaking) for 25 minutes. The reaction was concentrated in vacuo to dryness and the residue purified by preparative HPLC to yield the title compound 23 mg.

Workup

  1. waitThe reaction was left
  2. concentrationThe reaction was concentrated in vacuo to dryness
  3. customthe residue purified by preparative HPLC

Sources & evidence

ORD record
ord-05ab2b08b1224e22a8426801771fa1ed
Source dataset
uspto-grants-2011_05
Patent number
US07951810B2

Reaction notes

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