HCID 21864458, compound → HCID 55298736, compound

HRID 552738Notes

Reaction equation

HRID 552738 reaction equation
[C:1]([C:3]1[C:11]2[CH:10]=[N:9][CH:8]=[N:7][C:6]=2[NH:5][CH:4]=1)#[CH:2]>C(O)C.[OH-].[Pd+2].[OH-]>[CH2:1]([C:3]1[C:11]2[CH:10]=[N:9][CH:8]=[N:7][C:6]=2[NH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 1

HCID 21864458HCID 21864458, compound

Product 1

HCID 55298736HCID 55298736, compoundYield 86.2%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

5-ethynyl-7H-pyrrolo[2,3-d]pyrimidine (0.293 g, 2.05 mmol) and palladium hydroxide [20 weight percent (dry basis)] on carbon [moist] (0.0644 g, 0.0458 mmol) were stirred in ethanol (10 mL) under an atmosphere of hydrogen for 18 hours. The mixture was filtered through a pad of celite and concentrated to give the title compound as an orange solid (0.260 g, 86%).

Workup

  1. filtrationThe mixture was filtered through a pad of celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-807422ee1ad14c58bda74598bc09b078
Source dataset
uspto-grants-2011_05
Patent number
US07951810B2

Reaction notes

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