反应详情

To a solution of (2R,3S,5R)-5-(1H-pyrrolo[3,2-c]pyridin-1-yl)-2-{[(triisopropylsilyl)oxy]methyl}tetrahydrofuran-3-ol (0.487 g, 1.25 mmol) and a catalytic amount of DMAP in pyridine (1.6 mL) at 0° C. was added acetic anhydride (0.130 mL, 1.38 mmol) dropwise. The reaction was stirred overnight, concentrated, dissolved in EtOAc, washed with 1 M aq HCl (1×), water (1×) and brine (1×). The combined organics were washed with water (2×), dried (Na2SO4), filtered, and concentrated to give the title compound (0.464 g, 95%) which was used without further purification.

1. concentrationconcentrated
2. dissolutiondissolved in EtOAc
3. washwashed with 1 M aq HCl (1×), water (1×) and brine (1×)
4. washThe combined organics were washed with water (2×)
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated