Methyl iodide → Methyl 6-iodo-5-methoxypicolinate

HRID 55275Notes

Reaction equation

[I:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[C:4]([C:10]([OH:12])=[O:11])[N:3]=1.I[CH3:14]>>[CH3:14][O:11][C:10]([C:4]1[N:3]=[C:2]([I:1])[C:7]([O:8][CH3:9])=[CH:6][CH:5]=1)=[O:12]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 74719686-Iodo-5-methoxypyridine-2-carboxylic acid

Product 1

HCID 49766559Methyl 6-iodo-5-methoxypicolinate

Procedure

Under the conditions of example 1 D, 9.8 g of 2-iodo-3-methoxy-pyridine-6-carboxylic acid is reacted with 2.5 ml of iodomethane and worked up. 7.4 g of 2-iodo-3-methoxypyridine-6-carboxylic acid methyl ester of melting point 175°-178° C. is obtained.

Sources & evidence

ORD record: ord-569eeecdaff24d0eab83b6f7d8337f66
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05624943

Reaction notes

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