HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 178513593, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride hydrochloride | HCID 22141301 | — |
| Reactant | HCID 178524184 | HCID 178524184 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178513593 | HCID 178513593 | 99.6% |
Reaction Steps
To a solution of 1H-1,2,3-benzotriazole-5-carboxylic acid (2 g), EDCl/HCl (2.82 g), and HOBt in DMF (70 ml) was added an aqueous NH3 solution (5.1 ml), followed by reaction at room temperature for 2 hours. It was concentrated, and the residue was washed with a saturated NaHCO3 solution, collected by filtration, and dried to obtain 1H-1,2,3-benzotriazole-5-carboxamide (1.98 g) as a black solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951825B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-eb1c347199cb404cb53552f86cbe5bee |
| Source note | uspto-grants-2011_05 |