Ammonia → HCID 178513593, compound

HRID 552832Notes

Reaction equation

HRID 552832 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[N:2]1.CC[N:15]=C=NCCCN(C)C.Cl.Cl.C1C=CC2N(O)N=NC=2C=1.N>CN(C=O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([NH2:15])=[O:12])=[CH:9][C:4]=2[N:3]=[N:2]1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 757711-HydroxybenzotriazoleHCID 221413011-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride hydrochlorideHCID 178524184HCID 178524184, compound

Product 1

HCID 178513593HCID 178513593, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 1H-1,2,3-benzotriazole-5-carboxylic acid (2 g), EDCl/HCl (2.82 g), and HOBt in DMF (70 ml) was added an aqueous NH3 solution (5.1 ml), followed by reaction at room temperature for 2 hours. It was concentrated, and the residue was washed with a saturated NaHCO3 solution, collected by filtration, and dried to obtain 1H-1,2,3-benzotriazole-5-carboxamide (1.98 g) as a black solid.

Workup

  1. customfollowed by reaction at room temperature for 2 hours
  2. concentrationIt was concentrated
  3. washthe residue was washed with a saturated NaHCO3 solution
  4. filtrationcollected by filtration
  5. customdried

Sources & evidence

ORD record
ord-eb1c347199cb404cb53552f86cbe5bee
Source dataset
uspto-grants-2011_05
Patent number
US07951825B2

Reaction notes

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