Sodium Hydroxide → HCID 86750769, compound

HRID 55290Notes

Reaction equation

HRID 55290 reaction equation
C[O:2][C:3](=[O:39])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[CH:10][CH:9]=[C:8](/[CH:27]=[CH:28]\[C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([O:37]C)=[O:36])[CH:30]=2)[N:7]=1.[OH-].[Na+]>CO.O1CCCC1>[C:35]([C:31]1[CH:30]=[C:29](/[CH:28]=[CH:27]\[C:8]2[N:7]=[C:6]([CH2:5][CH2:4][C:3]([OH:39])=[O:2])[C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]/[C:19]3[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)=[CH:10][CH:9]=2)[CH:34]=[CH:33][CH:32]=1)([OH:37])=[O:36]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 867507703-{6-[2-(3-methoxycarbonyl-phenyl)-(1Z)-1-ethenyl]-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester

Product 1

HCID 86750769HCID 86750769, compoundYield 88.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Under the conditions of example 3 C, 82 mg of 3-{6-[2-(3-methoxycarbonyl-phenyl)-(1Z)-1-ethenyl]-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester in 2.5 ml of methanol and 1 ml of tetrahydrofuran is saponified with 2 ml of 2n sodium hydroxide solution and worked up. 69 mg of the title compound is obtained as colorless oil.

Sources & evidence

ORD record
ord-6f9c6fc48ccb43daa6f56931b13dd79f
Source dataset
uspto-grants-1997_04
Patent number
US05624943

Reaction notes

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