HRID55290

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

$结构：COC(=O)CCc1nc(/C=C\c2cccc(C(=O)OC)c2)ccc1OCCCC/C=C/c1ccc(OC)cc1$

HCID86750770

未命名化合物

PRODUCTS

生成物

$结构：COc1ccc(/C=C/CCCCOc2ccc(/C=C\c3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1$

HCID86750769

未命名化合物

收率 88.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Under the conditions of example 3 C, 82 mg of 3-{6-[2-(3-methoxycarbonyl-phenyl)-(1Z)-1-ethenyl]-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester in 2.5 ml of methanol and 1 ml of tetrahydrofuran is saponified with 2 ml of 2n sodium hydroxide solution and worked up. 69 mg of the title compound is obtained as colorless oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6f9c6fc48ccb43daa6f56931b13dd79f
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05624943
来源说明: uspto-grants-1997_04

反应 SMILES

C[O:2][C:3](=[O:39])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[CH:10][CH:9]=[C:8](/[CH:27]=[CH:28]\[C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([O:37]C)=[O:36])[CH:30]=2)[N:7]=1.[OH-].[Na+]>CO.O1CCCC1>[C:35]([C:31]1[CH:30]=[C:29](/[CH:28]=[CH:27]\[C:8]2[N:7]=[C:6]([CH2:5][CH2:4][C:3]([OH:39])=[O:2])[C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]/[C:19]3[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)=[CH:10][CH:9]=2)[CH:34]=[CH:33][CH:32]=1)([OH:37])=[O:36]