HCID 67703741, compound → HCID 54542739, compound

HRID 55292Notes

Reaction equation

HRID 55292 reaction equation
[CH3:1][O:2][C:3](=[O:18])/[CH:4]=[CH:5]/[C:6]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]([C:14]([O:16][CH3:17])=[O:15])[N:7]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]([C:14]([O:16][CH3:17])=[O:15])[N:7]=1

Participants

4

Reactant 1

HCID 67703741HCID 67703741, compound

Product 1

HCID 54542739HCID 54542739, compoundYield 72.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Under the conditions of example 1 C, a solution of 11 g of 3-(3-methoxy-6-methoxycarbonyl-2-pyridyl)-(2E)-2-propenoic acid methyl ester in 600 ml of methanol is hydrogenated in the presence of 2.2 g of 10% palladium catalyst on activated carbon, worked up, and the crude product is chromatographed on silica gel with hexane/0-25% ethyl acetate. 8 g of 3-(3-methoxy-6-methoxycarbonyl-2-pyridyl)-propionic acid methyl ester of melting point 98°-100° C. is obtained.

Workup

  1. customthe crude product is chromatographed on silica gel with hexane/0-25% ethyl acetate

Sources & evidence

ORD record
ord-0b274492804144a2a9b4e4998201d3e8
Source dataset
uspto-grants-1997_04
Patent number
US05624943

Reaction notes

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