反应详情

A solution of compound 78 (4.7 g, 15.650 mmol) in acetone (50 mL) was treated with 10% aq. HCl (50 mL) at room temperature and stirred for over night (14 h). Acetone was evaporated and crude was basified using 10% aq. NH4OH solution (100 mL). The precipitate was filtered off, washed with 10% NH4OH solution (2 10 mL) and water (2 10 mL). The product was dried under vacuum to obtain compound 79 (4.0 g, quantitative) as a solid. For spectral data, please see Example 23.

1. customAcetone was evaporated
2. filtrationThe precipitate was filtered off
3. washwashed with 10% NH4OH solution (2 10 mL) and water (2 10 mL)
4. customThe product was dried under vacuum