Methyl 3-methyl-2-butenoate → 3-Methyl-3-(4-nitro-imidazol-1-yl)-butyric acid methyl ester

HRID 553083Notes

Reaction equation

HRID 553083 reaction equation
[N+:1]([C:4]1[N:5]=[CH:6][NH:7][CH:8]=1)([O-:3])=[O:2].[CH3:9][O:10][C:11](=[O:16])[CH:12]=[C:13]([CH3:15])[CH3:14]>>[CH3:9][O:10][C:11](=[O:16])[CH2:12][C:13]([CH3:15])([N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[N:5]=[CH:6]1)[CH3:14]

Participants

3

Reactant 2

HCID 13546Methyl 3-methyl-2-butenoateHCID 178526856HCID 178526856, compound

Product 1

HCID 671649613-Methyl-3-(4-nitro-imidazol-1-yl)-butyric acid methyl ester

Procedure

4-nitroimidazole was reacted with methyl-3,3-dimethylacrylate to provide the title compound: 1H NMR (400 MHz, CDCl3) 1.74 (s, 6H), 2.81 (s, 2H), 3.57 (s, 3H), 7.57 (d, 1H, J=1.3 Hz), 7.90 (d, 1H, J=1.6 Hz); MS m/z 228.2 (M+1).

Sources & evidence

ORD record
ord-dc0cdd94270545fda44695cedbb1973c
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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