HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 553089Generated: October 30, 2026
Cesium carbonate → 4-(4-Nitro-imidazol-1-yl)-benzoic acid methyl ester
https://huagongshe.com/reaction/553089
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Iodo-methylbenzoate | HCID 22617896 | — |
| Reactant | HCID 178526856 | HCID 178526856 | — |
| Catalyst | Copper(I) trifluoromethanesulfonate | HCID 9813164 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-Nitro-imidazol-1-yl)-benzoic acid methyl ester | HCID 67164904 | — |
Reaction Steps
4-nitroimidazole (1 equiv) was combined with 4-iodo-methylbenzoate (1.2 equiv), cesium carbonate (1.0 equiv), copper (I) triflate (0.05 equiv), in DMF and heated overnight at 100° C. The solid was filtered and washed with methylene chloride, the resultant solvent was concentrated, and residue purified by silica gel chromatography to provide the title compound: MS m/z 248.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07951958B2 |
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| Source dataset | uspto-grants-2011_05 |
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| ORD ID | ord-917bfc393ef2480eabdfdf381cd7d2cf |
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| Source note | uspto-grants-2011_05 |
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