反应详情

温度

100 °C

4-nitroimidazole (1 equiv) was combined with 4-iodo-methylbenzoate (1.2 equiv), cesium carbonate (1.0 equiv), copper (I) triflate (0.05 equiv), in DMF and heated overnight at 100° C. The solid was filtered and washed with methylene chloride, the resultant solvent was concentrated, and residue purified by silica gel chromatography to provide the title compound: MS m/z 248.2 (M+1).

1. filtrationThe solid was filtered
2. washwashed with methylene chloride
3. concentrationthe resultant solvent was concentrated
4. customresidue purified by silica gel chromatography