Pyrrolidine → HCID 11698577, compound

HRID 553142Notes

Reaction equation

[CH3:1][C:2]([N:7]1[CH:11]=[C:10]([NH:12][C:13](=[O:30])[CH:14]([NH:18][C:19](=[O:29])[CH2:20][C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[CH:22]=2)[CH2:15][CH2:16][CH3:17])[N:9]=[CH:8]1)([CH3:6])[CH2:3][CH:4]=O.[NH:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH3:6][C:2]([N:7]1[CH:11]=[C:10]([NH:12][C:13](=[O:30])[CH:14]([NH:18][C:19](=[O:29])[CH2:20][C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[CH:22]=2)[CH2:15][CH2:16][CH3:17])[N:9]=[CH:8]1)([CH3:1])[CH2:3][CH2:4][N:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 86600812HCID 86600812, compound

Product 1

HCID 11698577HCID 11698577, compound

Procedure

2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid [1-(1,1-dimethyl-3-oxo-propyl)-1H-imidazol-4-yl]-amide was reacted with pyrrolidine to afford the title compound: C13 NMR (100 MHz, CDCl3) 14.0, 18.9, 23.6, 28.4, 28.7, 36.0, 42.1, 43.2, 51.3, 53.1, 54.4, 57.5, 103.0, 105.3, 112.4, 112.6, 131.2, 137.8, 169.0, 169.2. MS m/z 476.2 (M+1).

Sources & evidence

ORD record: ord-38994e556fc14f92be67cb4fc04454a9
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07951958B2

Reaction notes

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