Triethylamine → 2,6-dichloro-N-[2-(4-chlorophenyl)-1-methylethyl]benzamide

HRID 553194Notes

Reaction equation

HRID 553194 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([NH2:12])[CH3:11])=[CH:5][CH:4]=1.C(N(CC)CC)C.[Cl:20][C:21]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:22]=1[C:23](Cl)=[O:24].[Cl-].[NH4+]>ClCCl>[Cl:20][C:21]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:22]=1[C:23]([NH:12][CH:10]([CH3:11])[CH2:9][C:6]1[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=1)=[O:24]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 783922,6-Dichlorobenzoyl chlorideHCID 107161p-Chloroamphetamine hydrochloride

Product 1

HCID 167467792,6-dichloro-N-[2-(4-chlorophenyl)-1-methylethyl]benzamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

100 mg of 1-(4-chlorophenyl)propan-2-amine hydrochloride (0.728 mmol) and 0.10 ml of triethylamine (0.728 mmol) are diluted in 3 ml of dichloromethane at room temperature, 152 mg of 2,6-dichlorobenzoyl chloride (0.728 mmol) are added to the reaction mixture. After 24 hours of stirring, 20 ml of DCM an 10 ml of saturated solution of ammonium chloride are added to the reaction mixture.

Sources & evidence

ORD record
ord-8d496d9507bb4ad48530aa4d48f93f83
Source dataset
uspto-grants-2011_05
Patent number
US07951973B2

Reaction notes

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