反应详情

温度

100 °C

A 1 N sodium hydroxide aqueous solution (16.2 ml, 16.2 mmol) was added to an ethanol (15 ml) solution of the ((4-(5-benzoylbenzimidazol-2-yl)-3,5-dimethylpyrrol-2-yl)-carbonyl)-4-ethoxycarbonylpiperidine (4.19 g, 10.8 mmol) obtained in Example 44, and stirred at 100° C. for 4 hours. The reaction mixture was allowed to cool to room temperature with stirring, and then neutralized with 6 N hydrochloric acid (12 ml, 16.2 mmol). The precipitate was collected by filtration, and dried at reduced pressure to afford ((4-(5-benzoylbenzimidazol-2-yl)-3,5-dimethylpyrrol-2-yl)-carbonyl)piperidine-4-carboxylic acid (3.02 g, 78%) as white crystals.

1. temperatureto cool to room temperature
2. stirringwith stirring
3. filtrationThe precipitate was collected by filtration
4. customdried at reduced pressure