Hydrochloric Acid → HCID 67166220, compound

Participants

Reaction Steps

The 5-pyrrolidine-1-yl-methyl-furan-2-carboxylic acid ethyl ester (770 mg, 3.45 mmol) obtained in Example 55 (1) was dissolved in ethanol (4 ml). A 1 N sodium hydroxide aqueous solution (5.17 ml) was added dropwise to the solution, and the mixture was stirred overnight. The reaction mixture was neutralized with a 1 N hydrochloric acid solution (5.17 ml), and then ethanol was evaporated. The residue was dried to afford 5-pyrrolidine-1-yl-methyl-furan-2-carboxylic acid containing sodium chloride (1.08 g, sodium chloride content: 38% wt., quant.) as a white solid, which was used directly for the following reaction.

Provenance & Evidence