Hydrochloric Acid → HCID 67166220, compound

HRID 553250Notes

Reaction equation

HRID 553250 reaction equation
C([O:3][C:4]([C:6]1[O:7][C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:9][C:10]=1[CH3:11])=[O:5])C.[OH-].[Na+].Cl>C(O)C>[N:12]1([C:8]2[O:7][C:6]([C:4]([OH:5])=[O:3])=[C:10]([CH3:11])[CH:9]=2)[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67165963HCID 67165963, compound

Product 1

HCID 67166220HCID 67166220, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 5-pyrrolidine-1-yl-methyl-furan-2-carboxylic acid ethyl ester (770 mg, 3.45 mmol) obtained in Example 55 (1) was dissolved in ethanol (4 ml). A 1 N sodium hydroxide aqueous solution (5.17 ml) was added dropwise to the solution, and the mixture was stirred overnight. The reaction mixture was neutralized with a 1 N hydrochloric acid solution (5.17 ml), and then ethanol was evaporated. The residue was dried to afford 5-pyrrolidine-1-yl-methyl-furan-2-carboxylic acid containing sodium chloride (1.08 g, sodium chloride content: 38% wt., quant.) as a white solid, which was used directly for the following reaction.

Workup

  1. customethanol was evaporated
  2. customThe residue was dried

Sources & evidence

ORD record
ord-0880040c7f0b4ee2b78491ee96b2d59d
Source dataset
uspto-grants-2011_05
Patent number
US07951956B2

Reaction notes

Loading…