Hydrochloric Acid → KAA-276 free base

Participants

Reaction Steps

A pH of a solution of 5- [2- [4- (2-carboxyethyl)phenyl]ethyl]-1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane sodium salt (5.15 g) in distilled water (100 ml) was adjusted to pH 7 with a 2N-HCl. The resulting white precipitates were collected by filtration, washed with distilled water, and air-dried to give 5- [2- [4- (2-carboxyethyl)phenyl]ethyl]-1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane (4.30 g) as white crystals.

Provenance & Evidence