HRID55328

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：O=C(O)CCc1ccc(CCN2CCCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CCC2)cc1.[Na]

HCID67714921

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CCc1ccc(CCN2CCCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CCC2)cc1

HCID9871137

未命名化合物

收率 87.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A pH of a solution of 5- [2- [4- (2-carboxyethyl)phenyl]ethyl]-1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane sodium salt (5.15 g) in distilled water (100 ml) was adjusted to pH 7 with a 2N-HCl. The resulting white precipitates were collected by filtration, washed with distilled water, and air-dried to give 5- [2- [4- (2-carboxyethyl)phenyl]ethyl]-1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane (4.30 g) as white crystals.

WORKUP

后处理

customThe resulting white precipitates
filtrationwere collected by filtration
washwashed with distilled water
customair-dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-355aa40250864d38ae882a3e07c1fb72
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05624948
来源说明: uspto-grants-1997_04

反应 SMILES

[Na].[C:2]([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][N:15]2[CH2:22][CH2:21][CH2:20][N:19]([C:23]3[N:27]([CH2:28][C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=4)[C:26]4[CH:36]=[CH:37][CH:38]=[CH:39][C:25]=4[N:24]=3)[CH2:18][CH2:17][CH2:16]2)=[CH:9][CH:8]=1)([OH:4])=[O:3].Cl>O>[C:2]([CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][N:15]2[CH2:22][CH2:21][CH2:20][N:19]([C:23]3[N:27]([CH2:28][C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=4)[C:26]4[CH:36]=[CH:37][CH:38]=[CH:39][C:25]=4[N:24]=3)[CH2:18][CH2:17][CH2:16]2)=[CH:11][CH:12]=1)([OH:4])=[O:3]