Hydrochloric Acid → KAA-276 free base

HRID 55328Notes

Reaction equation

HRID 55328 reaction equation
[Na].[C:2]([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][N:15]2[CH2:22][CH2:21][CH2:20][N:19]([C:23]3[N:27]([CH2:28][C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=4)[C:26]4[CH:36]=[CH:37][CH:38]=[CH:39][C:25]=4[N:24]=3)[CH2:18][CH2:17][CH2:16]2)=[CH:9][CH:8]=1)([OH:4])=[O:3].Cl>O>[C:2]([CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][N:15]2[CH2:22][CH2:21][CH2:20][N:19]([C:23]3[N:27]([CH2:28][C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=4)[C:26]4[CH:36]=[CH:37][CH:38]=[CH:39][C:25]=4[N:24]=3)[CH2:18][CH2:17][CH2:16]2)=[CH:11][CH:12]=1)([OH:4])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67714921HCID 67714921, compound

Product 1

HCID 9871137KAA-276 free baseYield 87.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A pH of a solution of 5- [2- [4- (2-carboxyethyl)phenyl]ethyl]-1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane sodium salt (5.15 g) in distilled water (100 ml) was adjusted to pH 7 with a 2N-HCl. The resulting white precipitates were collected by filtration, washed with distilled water, and air-dried to give 5- [2- [4- (2-carboxyethyl)phenyl]ethyl]-1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane (4.30 g) as white crystals.

Workup

  1. customThe resulting white precipitates
  2. filtrationwere collected by filtration
  3. washwashed with distilled water
  4. customair-dried

Sources & evidence

ORD record
ord-355aa40250864d38ae882a3e07c1fb72
Source dataset
uspto-grants-1997_04
Patent number
US05624948

Reaction notes

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