(S)-1-methoxybutan-2-amine hydrochloride → (1-Methoxymethyl-propyl)-{3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-benzyl}-amine
Reaction equation
Cl.[CH3:2][O:3][CH2:4][C@@H:5]([NH2:8])[CH2:6][CH3:7].[O:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[O:15][CH2:16][CH2:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH:21]=O>>[CH3:2][O:3][CH2:4][CH:5]([NH:8][CH2:21][C:20]1[CH:23]=[CH:24][CH:25]=[C:18]([CH2:17][CH2:16][O:15][CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][O:9]2)[CH:19]=1)[CH2:6][CH3:7]Participants
3
Procedure
The sub-titled compound was prepared from (S)-1-methoxymethyl-propylamine hydrochloride (0.36 g) and 3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-benzaldehyde (Example 50, step a, 0.5 g) using the method of Example 75, step b. Yield 0.6 g.
Sources & evidence
- ORD record
- ord-87b9dad2a7c44b62a0349d7333cb740c
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07951954B2
Reaction notes
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