Benzathine → HCID 67462775, compound

HRID 553406Notes

Reaction equation

HRID 553406 reaction equation
[CH2:1]([NH:8][CH2:9][CH2:10][NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:19]#[C:20]Br>>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:20]1=[NH:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8793BenzathineHCID 10476Cyanogen Bromide

Product 1

HCID 67462775HCID 67462775, compound

Procedure

The title compound was prepared in one step from N,N′-dibenzylethylenediamine and cyanogen bromide as described in Procedure A. The precipitated solid was filtered off the reaction mixture, washed with acetonitrile and recrystallized from MeOH to give the title compound as a hydrogen bromide salt. 1NMR (DMSO-d6) δ 3.48 (s, 4H), 4.61 (s, 4H), 7.32-7.46 (m, 10H), 8.51 (s, 2H). MS (ES+) m/z 266 ([M+1]+, 100).

Workup

  1. filtrationThe precipitated solid was filtered off the reaction mixture
  2. washwashed with acetonitrile
  3. customrecrystallized from MeOH

Sources & evidence

ORD record
ord-d31747627a3345cbaa03bda352f83eeb
Source dataset
uspto-grants-2011_11
Patent number
US08048877B2

Reaction notes

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