Cyclopropanemethanamine → HCID 57434473, compound

HRID 553424Notes

Reaction equation

HRID 553424 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[O:14][N:15]=[C:16]([C:17]([OH:19])=O)[C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:20]1([CH2:23][NH2:24])[CH2:22][CH2:21]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[O:14][N:15]=[C:16]([C:17](=[O:19])[NH:24][CH2:23][CH:20]3[CH2:22][CH2:21]3)[C:10]=2[CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 576186225-(1,1-Dimethylethyl) 6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

Product 1

HCID 57434473HCID 57434473, compoundYield 78%

Procedure

In a manner similar to general method 1, 280 mg (1.0 mmol) of 6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester were reacted with 90 μL of cyclopropylmethylamine to yield 260 mg (78% of theoretical) of 3-(cyclopropylmethyl-carbamoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester, which were obtained in the form of a yellow oil.

Sources & evidence

ORD record
ord-8cff61c06ad540ab90ca30614e438f38
Source dataset
uspto-grants-2011_11
Patent number
US08048879B2

Reaction notes

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