HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-(2-sulfamoylphenoxy)-N-methylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Reactant | 2-Hydroxybenzene-1-sulfonamide | HCID 637546 | — |
| Reactant | 2-Bromo-N-methylacetamide | HCID 15490745 | — |
| Product | 2-(2-sulfamoylphenoxy)-N-methylacetamide | HCID 57924329 | — |
Reaction Steps
2-(2-Sulfamoylphenoxy)-N-methylacetamide can be prepared according to the method of Scheme XXXIX. Bromoacetyl bromide can be reacted methylamine hydrochloride in the presence of a base, such as sodium hydroxide to afford 2-bromo-N-methylacetamide. The phenoxy group of 1-(hydroxy)-2-sulfamoylbenzene can be alkylated with 2-bromo-N-methylacetamide in the presence of a base, such as cesium carbonate, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, and the like, to afford 2-(2-sulfamoylphenoxy)-N-methylacetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048862B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-03d8eda5f97b4236b8da1b60fe3c20b6 |
| Source note | uspto-grants-2011_11 |