HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86761432, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(4-BOC-piperazino)-2-chloropyridine | HCID 59321836 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86761432 | HCID 86761432 | 99% |
Reaction Steps
Dissolve 4-(2-chloro-pyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester (8.300 g, 27.872 mmol) in dichloromethane (200 mL). Slowly add 4N HCl in dioxane (42 mL). Stir at room temperature for 8 hours. Concentrate and wash the resulting solid with diethyl ether to afford the title preparation (7.500 g, 99% yield). MS ES: m/z=198 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048884B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-252f13cc888f4709ac9e2118376d21e6 |
| Source note | uspto-grants-2011_11 |