Hydrochloric Acid → HCID 86761432, compound

HRID 553494Notes

Reaction equation

HRID 553494 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:15]([Cl:20])=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>ClCCl.O1CCOCC1>[ClH:20].[Cl:20][C:15]1[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:19][CH:18]=[CH:17][N:16]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 593218363-(4-BOC-piperazino)-2-chloropyridine

Product 1

HCID 86761432HCID 86761432, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

Dissolve 4-(2-chloro-pyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester (8.300 g, 27.872 mmol) in dichloromethane (200 mL). Slowly add 4N HCl in dioxane (42 mL). Stir at room temperature for 8 hours. Concentrate and wash the resulting solid with diethyl ether to afford the title preparation (7.500 g, 99% yield). MS ES: m/z=198 [M+H]+.

Workup

  1. concentrationConcentrate
  2. washwash the resulting solid with diethyl ether
  3. customto afford the title
  4. custompreparation (7.500 g, 99% yield)

Sources & evidence

ORD record
ord-252f13cc888f4709ac9e2118376d21e6
Source dataset
uspto-grants-2011_11
Patent number
US08048884B2

Reaction notes

Loading…