反应详情

Cool a solution of methylaminoacetaldehyde dimethyl acetal (22.5 mL, 0.18 mol) and triethylamine (26.5 mL, 0.19 mol) to 0° C. in CH2Cl2, then add dropwise a solution of 1-methyl-1H-pyrazole-4-sulfonyl chloride (30 g, 0.17 mol). Stir the reaction mixture at room temperature overnight, dilute with CH2Cl2 (500 mL), and wash with water. Dry the combined organics over Na2SO4, filter and concentrate. The resulting oil is placed under high vacuum and within two hours a resulting off white solid is formed, which is used without further purification (38.22 g, 87%).

1. washwash with water
2. dry with materialDry the combined organics over Na2SO4
3. filtrationfilter
4. concentrationconcentrate
5. waitThe resulting oil is placed under high vacuum and within two hours
6. customa resulting off white solid is formed
7. customwhich is used without further purification (38.22 g, 87%)