Trifluoroacetic acid → HCID 57671635, compound

HRID 553530Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][N:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[C:6]([C:14]([NH:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])=[O:15])=[C:5]2[OH:25].C(O)(C(F)(F)F)=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][N:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[C:6]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])=[C:5]2[OH:25]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57671657HCID 57671657, compound

Product 1

HCID 57671635HCID 57671635, compound

Procedure

The title compound was prepared similarly to the procedure described for Example 1 (g), by treatment of tert-butyl 2-(6-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,7-naphthyridine-3-carboxamido)acetate (Example 105 (i)) with TFA. MS (ESI, pos. ion) m/z: 310 (M+1). 1H NMR (400 MHz, DMSO-d6) δ ppm: 10.46 (s, 1 H), 8.91 (s, 1 H), 7.94 (s, 1 H), 4.15 (d, J=5.5 Hz, 2 H), 3.69 (s, 3 H).

Sources & evidence

ORD record: ord-f08b1f5321a345828931d163e4ea4442
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08048892B2

Reaction notes

Loading…