Ethanol → Ethyl 3-(bromophenyl)acetate

HRID 553676Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[CH2:17]([O:10][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[CH3:18]

Participants

Reactant 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 74653(3-Bromophenyl)acetic acid

Product 1

HCID 11470552Ethyl 3-(bromophenyl)acetate

Procedure

3-Bromophenylacetic acid (0.31 mmol) was treated with concentrated sulfuric acid in ethanol at reflux for 2 hours to give (3-bromo-phenyl)-acetic acid ethyl ester.

Workup

temperatureat reflux for 2 hours

Sources & evidence

ORD record: ord-24a2f2e0f6d64ebbafe53850d2bbe8f8
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08048902B2

Reaction notes

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